Endocrine Abstracts

Background: Statin medication is commonly used in prevention of cardiovascular diseases. Pooled evidence shows that statin therapy is associated with increased risk of incident diabetes, but studies vary in results and there is no consensus of the diabetogenic mechanism of statins. Beta blockers and diuretics are commonly used antihypertensive agents that also have been shown to increase the risk of incident diabetes. Our objective was to examine the effects of statins, beta b...

Background and aimsMonogenic forms of diabetes caused by a single gene defect include maturity onset diabetes of the young (MODY), neonatal diabetes mellitus and syndromic forms. They are estimated to account for 1–3% of all diabetes cases, but the prevalence is higher among pediatric patients without islet autoantibodies (AAB). Despite presenting with insulin deficiency, many patients can be treated with anti-hyperglycaemic agents to stimulate the...